dōTERRA Cardamom Study

A flavorful and distinctive spice, Cardamom is known as the “queen of spices” in the cooking world. However, the essential oil that comes from cardamom seeds has uses that reach far beyond the kitchen. Cardamom essential oil has been widely used topically primarily due to its calming and soothing properties. These properties are largely attributed to its high content of monoterpenoids. Specifically, doTERRA Cardamom essential oil is known for its rich concentration of 1, 8-cineole (also known as eucalyptol).


A recently published scientific paper from doTERRA showed that Cardamom essential oil strongly inhibited the protein level of vascular cell adhesion molecule 1 (VCAM-1) in human skin cells. VCAM-1 is an important protein biomarker of a normal inflammatory response. Gene expression analysis showed that Cardamom essential oil robustly impacted the expression levels of 21,224 human genes. Many of these impacted genes are closely related to inflammation, immune response, and tissue remodeling. The study findings suggest that not only is Cardamom essential oil biologically active in human skin cells, but also it highly impacts important proteins and genes in critical pathways.


To the best of our knowledge, this is the first ever published study on the biological activities of Cardamom essential oil in human skin cells. The findings are largely consistent with existing studies of Cardamom essential oil in other models, supporting its positive effects.


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