Beyond Healthy Inflammatory Response: Epigenetics Meets Essential Oils

Frankincense has long been considered a sacred resin for mood and meditation—but when combined with Boswellic Acid, it becomes something far more powerful: an epigenetic conductor, capable of retuning the body’s most critical cellular symphonies.

A recent clinical trial led by doTERRA examined how daily use of doTERRA Frankincense Boswellic Acid Complex (BAC) supplement—containing both Frankincense oil and concentrated boswellic acids—impacts inflammatory response, gene expression, and physical and emotional health. The results weren’t subtle. The supplement induced methylation changes across more than 12,000 genes, engaging systems as diverse as hormone regulation, cognition, mitochondrial metabolism, detoxification, and stress response in the healthy participants.*

This is more than a botanical “calm down” pill. It’s a system-wide recalibration for those navigating modern biological chaos.*

5 Science-Backed Takeaways

1. Enhanced Neuroplasticity and Cognitive Resilience

Genes like BDNF, DRD2, FOXP2, and GDNF were activated, supporting brain growth, memory encoding, emotional regulation, and long-term cognitive flexibility.*

Analogy: Like updating your brain’s operating system while defragmenting memory and enhancing emotional RAM.*

2. Epigenetic Inflammatory System Recalibration

Methylation patterns downregulated inflammatory pathways (e.g., IL6, NF-κB, STAT3) while upregulating healthy inflammatory response signals (e.g., IL10, FOXO3).*

Analogy: It doesn’t slam the brakes—it adjusts your immune system’s cruise control for the terrain ahead.*

3. Hepatic & Renal Function Optimization

Significant reductions in liver enzymes (ALT, AST, ALP) and improved markers of kidney clearance (BUN, eGFR) suggest detox and fluid regulation support.*

Analogy: Think of it as an oil change for your liver and a filter flush for your kidneys.*

4. DNA Repair, Longevity, and Stress Resilience

Longevity genes (TP53, ATM, SIRT1, FOXO3) and stress response genes (MTOR, AKT1) showed favorable epigenetic modulation.*

Analogy: It’s as if your cells remembered how to clean, repair, and protect themselves—before chaos took root.*

Clinical Meets Practical: What This Means for You

Real-Life Examples

• Regulates the inflammatory system, so your body knows when to fight and when to chill.*
• Supports your liver and kidneys like a natural cleanup crew.*
• Upregulates genes associated with cognitive function, which may help you think faster and feel calmer.*
  • Modulates genes associated with DNA repair, which may protect your cells from getting tired, old, or overwhelmed.*

Unique Science Nuggets

• Over 12,000 genes were epigenetically affected—vs. about 1200 in Frankincense alone.*
• Upregulation of mitochondrial and DNA repair pathways imitated the longevity benefits of caloric restriction and fasting-mimicking states.*
• Downregulation of inflammatory and stress-response genes suggests neuroendocrine and immune recalibration, not suppression.*

Suggested Routine

Morning:

• Take 2 capsules with a fat-containing meal
• Pair with EO Mega^®+ or VMG+^® for enhanced absorption*

Evening:

• Use with magnesium or adaptogens for sleep and nervous system synergy*
• Diffuse Frankincense oil or use topically for its comforting aroma and soothing skin benefits.

_*以上聲稱尚未經過美國食品藥物管理局認證。本產品並無意用於診斷，治療或防止疾病。